journalINTERNATIONAL JOURNAL OF ENVIRONMENT AND HEALTH SCISVolume 2 Issue 2MultidisciplinaryEnglish2020NNY20200625ArticleVASCULAR DISEASES AND ROLE OF NITRIC OXIDEEnglishY99114KushalChakraborty1EnglishNMd. IqbalAlam2EnglishYGausal AzamKhan1*EnglishY10.47062/1190.0202.04Endothelium, the inner-most layers of blood vessels is an active monolayer of cells which has been evolved to become specialized barrier between blood and other structures of the vessel wall. Endothelial cell layer is known to communicate between blood and extravascular tissues and is actively involved in cardiovascular homeostasis. Intact endothelium regulates vascular tone, permeability and maintains non-inflammatory, anti-thrombotic surface. Through its ability to express procoagulants, anticoagulants, vasoconstrictors, vasodilators, cell adhesion molecules and cytokines, the endothelium has emerged as one of the pivotal regulators of haemostasis. Under normal conditions, endothelial cell sustains a vasodilatory, anticoagulant and fibrinolytic state in which coagulation, platelet adhesion as well as leukocyte activation and inflammation are suppressed by continuous release of nitric oxide (NO). Endothelium plays a major role in development of cardiovascular diseases (CVDs). Endothelial cell injuries and resultant endothelial dysfunction (ED) plays a key role in the deployment of CVDs. Therefore, the imbalance of endothelial function due to suppression of anticoagulant molecules like nitric oxide (NO), tissue factor pathway inhibition (TFPI), thrombomodulin etc, and over expression of procoagulant molecules like tissue actor (TF), endothelin-1, von Willebrand factor (vWF), plasminogen activator inhibitor (PAI)-1 secreted by endothelial surface isseen during stress. Several factors like infection, hyperglycaemia, hyperlipidaemia, malignancy, oxidative stress, and aging can interfere with endothelial function. It is widely believed, that ED plays a crucial role in the development of cardiovascular diseases. Also it has been reported to be involved in atherosclerosis, thrombosis, hypertension, diabetes and other vascular conditions. In this article we will specifically highlight andreview the role ofED in different vascular conditions.EnglishNitric Oxide, CVDs, hypertension, thrombosis, inflammation, stress..https://journal.stenvironment.org/abstract?id=164References1619